منابع مشابه
SMAD transcription factors are altered in cell models of HD and regulate HTT expression
Transcriptional dysregulation is observable in multiple animal and cell models of Huntington's disease, as well as in human blood and post-mortem caudate. This contributes to HD pathogenesis, although the exact mechanism by which this occurs is unknown. We therefore utilised a dynamic model in order to determine the differential effect of growth factor stimulation on gene expression, to highlig...
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Myostatin, a member of the transforming growth factor (TGF)-beta family, plays an important role in regulating skeletal muscle growth and differentiation. Here we examined the role of FoxO1 and SMAD transcription factors in regulating myostatin gene expression and myoblast differentiation in C(2)C(12) myotubes in vitro. Both myostatin and FoxO1 mRNA expression were greater in fast- vs. slow-twi...
متن کاملAntagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans.
The C. elegans daf-8 gene encodes an R-Smad that is expressed in a subset of head neurons, the intestine, gonadal distal tip cells and the excretory cell. We found that DAF-8, which inhibits the DAF-3 Co-Smad, is associated with DAF-3 and the DAF-14 Smad in vivo and in vitro. Overexpression of daf-8 conferred a dauer-defective phenotype and suppressed constitutive dauer formation in daf-8 and d...
متن کاملACCELERATED COMMUNICATION Regulation of Smad-Mediated Gene Transcription by RGS3
Regulator of G protein signaling (RGS) proteins are united into a family by the presence of the homologous RGS domain that binds the subunits of heterotrimeric G proteins and accelerates their GTPase activity. A member of this family, RGS3 regulates the signaling mediated by Gq and Gi proteins by binding the corresponding G subunits. Here we show that RGS3 interacts with the novel partners Smad...
متن کاملRegulation of Smad-mediated gene transcription by RGS3.
Regulator of G protein signaling (RGS) proteins are united into a family by the presence of the homologous RGS domain that binds the alpha subunits of heterotrimeric G proteins and accelerates their GTPase activity. A member of this family, RGS3 regulates the signaling mediated by G(q) and G(i) proteins by binding the corresponding Galpha subunits. Here we show that RGS3 interacts with the nove...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2005
ISSN: 0890-9369
DOI: 10.1101/gad.1350705